Research Papers: General

Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media

[+] Author Affiliations
Adam R. Gardner

Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92697-3010

University of California, Department of Chemical Engineering and Materials Science, 916 Engineering Tower, Irvine, California 92697-2575

Carole K. Hayakawa

Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92697-3010

University of California, Department of Chemical Engineering and Materials Science, 916 Engineering Tower, Irvine, California 92697-2575

Vasan Venugopalan

Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92697-3010

University of California, Department of Chemical Engineering and Materials Science, 916 Engineering Tower, Irvine, California 92697-2575

J. Biomed. Opt. 19(6), 065003 (Jun 27, 2014). doi:10.1117/1.JBO.19.6.065003
History: Received October 17, 2013; Revised March 27, 2014; Accepted April 22, 2014
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Abstract.  We present a coupled forward-adjoint Monte Carlo (cFAMC) method to determine the spatially resolved sensitivity distributions produced by optical interrogation of three-dimensional (3-D) tissue volumes. We develop a general computational framework that computes the spatial and angular distributions of the forward-adjoint light fields to provide accurate computations in mesoscopic tissue volumes. We provide full computational details of the cFAMC method and provide results for low- and high-scattering tissues probed using a single pair of optical fibers. We examine the effects of source-detector separation and orientation on the sensitivity distributions and consider how the degree of angular discretization used in the 3-D tissue model impacts the accuracy of the resulting absorption sensitivity profiles. We discuss the value of such computations for optical imaging and the design of optical measurements.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Adam R. Gardner ; Carole K. Hayakawa and Vasan Venugopalan
"Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media", J. Biomed. Opt. 19(6), 065003 (Jun 27, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.6.065003


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