Research Papers: Imaging

X-ray micromodulated luminescence tomography in dual-cone geometry

[+] Author Affiliations
Wenxiang Cong

Rensselaer Polytechnic Institute, Department of Biomedical Engineering, 110 8th Street, Troy, New York 12180

Zhengwei Pan

University of Georgia, Department of Physics and Astronomy, Athens, Georgia 30602

Robert Filkins, Alok Srivastava, Nadeem Ishaque

GE Global Research Center, 1 Research Circle, Niskayuna, New York 12309

Plamen Stefanov

Purdue University, Department of Mathematics, 150N University Street, West Lafayette, Indiana 47907

Ge Wang

Rensselaer Polytechnic Institute, Department of Biomedical Engineering, 110 8th Street, Troy, New York 12180

J. Biomed. Opt. 19(7), 076002 (Jul 02, 2014). doi:10.1117/1.JBO.19.7.076002
History: Received April 3, 2014; Revised May 22, 2014; Accepted May 28, 2014
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Abstract.  We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or a small animal. For this purpose, x-rays are focused through a polycapillary lens onto a spot of a few micrometers in size. Such x-ray scanning can be point-wise performed to acquire photon emission data on an object surface. The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth. We describe several numerical simulation studies to demonstrate the feasibility and merits of the proposed approach.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Wenxiang Cong ; Zhengwei Pan ; Robert Filkins ; Alok Srivastava ; Nadeem Ishaque, et al.
"X-ray micromodulated luminescence tomography in dual-cone geometry", J. Biomed. Opt. 19(7), 076002 (Jul 02, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076002


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