Research Papers: Imaging

Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans

[+] Author Affiliations
Brendan F. Kennedy

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Francisco Gomes Malheiro

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Lixin Chin

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

David D. Sampson

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

The University of Western Australia, Centre for Microscopy, Characterisation and Analysis, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 19(7), 076006 (Jul 07, 2014). doi:10.1117/1.JBO.19.7.076006
History: Received May 5, 2014; Revised June 6, 2014; Accepted June 9, 2014
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Abstract.  We present an acquisition method for optical coherence elastography (OCE) that enables acquisition of three-dimensional elastograms in 5 s, an order of magnitude faster than previously reported. In this method, based on compression elastography, the mechanical load applied to the sample is altered between acquisitions of consecutive optical coherence tomography volume scans (C-scans). The voxel-by-voxel phase difference between the volumes is used to determine the axial displacement and determining the gradient of the axial displacement versus depth gives the local axial strain. We demonstrate sub-100-microstrain sensitivity and high contrast in elastograms, acquired in 5 s, of structured phantoms and freshly excised rat muscle tissue that are comparable in strain sensitivity and dynamic range to our previously reported B-scan-based method. The much higher acquisition speed may expedite the translation of OCE to clinical and in vivo applications.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Brendan F. Kennedy ; Francisco Gomes Malheiro ; Lixin Chin and David D. Sampson
"Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans", J. Biomed. Opt. 19(7), 076006 (Jul 07, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076006


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