Research Papers: Imaging

Mesoscopic reflectance angular domain spectroscopic imaging

[+] Author Affiliations
Yan Zhang

Simon Fraser University, School of Engineering Science, Burnaby, British Columbia V5S 1S6, Canada

Fartash Vasefi

Simon Fraser University, School of Engineering Science, Burnaby, British Columbia V5S 1S6, Canada

Lawson Health Research Institute, Imaging Program, St. Joseph’s Health Care, London, Ontario N6A 4V2, Canada

Eldon Ng

Lawson Health Research Institute, Imaging Program, St. Joseph’s Health Care, London, Ontario N6A 4V2, Canada

University of Western Ontario, Schulich School of Medicine and Dentistry, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada

Astrid Chamson-Reig

Lawson Health Research Institute, Imaging Program, St. Joseph’s Health Care, London, Ontario N6A 4V2, Canada

Bozena Kaminska

Simon Fraser University, School of Engineering Science, Burnaby, British Columbia V5S 1S6, Canada

Jeffrey J. L. Carson

Lawson Health Research Institute, Imaging Program, St. Joseph’s Health Care, London, Ontario N6A 4V2, Canada

University of Western Ontario, Schulich School of Medicine and Dentistry, Department of Medical Biophysics, London, Ontario N6A 3K7, Canada

J. Biomed. Opt. 19(7), 076010 (Jul 14, 2014). doi:10.1117/1.JBO.19.7.076010
History: Received August 30, 2013; Revised May 17, 2014; Accepted May 22, 2014
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Abstract.  The advancement of angular domain imaging in mesoscopic reflectance multispectral imaging is reported. The key component is an angular filter array that performs the angular filtration of the back-scattered photons and generates image contrast due to the variances in tissue optical properties. The proposed modality enables multispectral imaging of subsurface features for samples too thick for transillumination angular domain spectroscopic imaging (ADSI) approaches. The validation was carried out with tissue-mimicking phantoms with multiple absorptive features embedded below the surface. Multispectral images in the range of 666 to 888 nm clearly revealed the location of the features with the background scattering levels up to 20cm1. The shape of the features was recoverable at depths of up to three to four times the transport mean free path. The spatial resolution was <1mm and the field-of-view was larger than 2.5cm×3.0cm. Furthermore, the attenuation spectra of measured absorptive features were successfully extracted. Target detectability and imaging quality with different background scattering levels, target depths, and illumination focal depths were discussed, as well as the capability of ADSI in reflectance optical mesoscopic imaging and its potential applications.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Yan Zhang ; Fartash Vasefi ; Eldon Ng ; Astrid Chamson-Reig ; Bozena Kaminska, et al.
"Mesoscopic reflectance angular domain spectroscopic imaging", J. Biomed. Opt. 19(7), 076010 (Jul 14, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076010


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