Research Papers: Imaging

Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues

[+] Author Affiliations
E Du, Minghao Sun, Yihong Guo, Hui Ma

Tsinghua University, Department of Physics, Beijing 100084, China

Tsinghua University, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, China

Honghui He, Nan Zeng, Jian Wu

Tsinghua University, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, China

Shaoxiong Liu

Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Sixth People’s Hospital (Nanshan Hospital), Shenzhen 518052, China

J. Biomed. Opt. 19(7), 076013 (Jul 15, 2014). doi:10.1117/1.JBO.19.7.076013
History: Received June 4, 2014; Revised June 26, 2014; Accepted June 26, 2014
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Abstract.  Polarization measurements allow one to enhance the imaging contrast of superficial tissues and obtain new polarization sensitive parameters for better descriptions of the micro- and macro- structural and optical properties of complex tissues. Since the majority of cancers originate in the epithelial layer, probing the morphological and pathological changes in the superficial tissues using an expended parameter set with improved contrast will assist in early clinical detection of cancers. We carry out Mueller matrix imaging on different cancerous tissues to look for cancer specific features. Using proper scattering models and Monte Carlo simulations, we examine the relationship between the microstructures of the samples, which are represented by the parameters of the scattering model and the characteristic features of the Mueller matrix. This study gives new clues on the contrast mechanisms of polarization sensitive measurements for different cancers and may provide new diagnostic techniques for clinical applications.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

E Du ; Honghui He ; Nan Zeng ; Minghao Sun ; Yihong Guo, et al.
"Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues", J. Biomed. Opt. 19(7), 076013 (Jul 15, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076013


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