The elastic scattering of light offers a highly sensitive probing mechanism to characterize changes in morphology and ultrastructure at various size scales ranging from nanometers to millimeters.1,2 Creative ways to measure light scattering signals can allow macroscopic measurements to inform the microscopic and even submicroscopic properties of a variety of materials as diverse as metal surfaces and cell suspensions. However, in conventional wide-field imaging of dense random media, such as biological tissue, the sensitivity of scattered light to ultrastructural changes is often reduced by the strong influences of multiple scattering events and rendered less specific because of the confounding effects of molecular absorption by tissue chromophores such as hemoglobin, lipids, and water. While these absorbers can be diagnostically powerful, in many situations, such as in surgery, the ability to remove the effects of absorption (e.g., from the presence of surface blood) from the image and to simply visualize scatter changes would be valuable. Several confocal and specialized fiber-based scanning approaches3,4 have been developed to probe or image optical property variations in cells and tissue surfaces. But almost all these techniques rely on semianalytical or empirical light-transport models to separate absorption effects from scattering. Direct measurement of light scattering signals using spatial and angular localization techniques has been proposed recently using a confocal and dark-field optical scheme.5,6 However, a critical limitation of the approach is that the wide-field imaging (several centimeters) requires electro-optical or mechanical scanning, which is time consuming and cumbersome, and hence, impractical in many clinical applications.