Research Papers: Imaging

Cost-efficient laser-diode-induced optical-resolution photoacoustic microscopy for two-dimensional/three-dimensional biomedical imaging

[+] Author Affiliations
Lvming Zeng, Guodong Liu

Jiangxi Sciences and Technology Normal University, Key Laboratory of Optic-Electronic and Communication, Nanchang 330038, China

Diwu Yang

Hunan University of Technology, Department of Physics and Engineering, Zhuzhou 412000, China

Xuanrong Ji

Doppler Electronic Technologies Company Ltd., Guangzhou 510663, China

J. Biomed. Opt. 19(7), 076017 (Jul 24, 2014). doi:10.1117/1.JBO.19.7.076017
History: Received April 28, 2014; Revised June 18, 2014; Accepted July 7, 2014
Text Size: A A A

Abstract.  Solid-state laser systems, such as traditional Nd:YAG-based lasers, are commonly used for noninvasive biomedical photoacoustics with nanosecond pulse duration and millijoule pulse energy. However, such lasers are both bulky and expensive for use as a handy tool for clinical applications. As an alternative, a semiconductor light source has the advantages of being compact, inexpensive, and robust. In addition, the main drawback of low peak output power may make it exactly suitable for the imaging modalities, which require relatively low pulse energies, such as acoustic- and optical-resolution photoacoustic microscopy (AR/OR-PAM). We propose a cost-efficient OR-PAM for two-dimensional/three-dimensional (2-D/3-D) biological imaging based on a pulsed near-infrared laser diode. By raster scanning, typical 2-D photoacoustic images were obtained at different scales, and 3-D surface renderings were clearly reconstructed with a marching cubes algorithm. This initial study would promote the production of portable OR-PAM technology for clinical and biomedical applications.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Lvming Zeng ; Guodong Liu ; Diwu Yang and Xuanrong Ji
"Cost-efficient laser-diode-induced optical-resolution photoacoustic microscopy for two-dimensional/three-dimensional biomedical imaging", J. Biomed. Opt. 19(7), 076017 (Jul 24, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076017


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.