Research Papers: Imaging

Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization

[+] Author Affiliations
Umar Alqasemi

King Abdulaziz University, Department of Electrical and Computer Engineering, PO Box 80204, Jeddah 21589, Saudi Arabia

University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States

Hai Li

University of Connecticut, Departments of Electrical and Computer Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States

Guangqian Yuan, Patrick Kumavor, Saeid Zanganeh

University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States

Quing Zhu

University of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States

University of Connecticut, Departments of Electrical and Computer Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United States

J. Biomed. Opt. 19(7), 076020 (Jul 28, 2014). doi:10.1117/1.JBO.19.7.076020
History: Received November 7, 2013; Revised June 12, 2014; Accepted July 7, 2014
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Abstract.  Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Umar Alqasemi ; Hai Li ; Guangqian Yuan ; Patrick Kumavor ; Saeid Zanganeh, et al.
"Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization", J. Biomed. Opt. 19(7), 076020 (Jul 28, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076020


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