Research Papers: Imaging

Viscous optical clearing agent for in vivo optical imaging

[+] Author Affiliations
Zijian Deng

Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China

Lijia Jing

Harbin Institute of Technology, School of Life Science and Technology, Harbin 150001, China

Ning Wu

Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China

Pengyu lv

Peking University, College of Engineering, Department of Mechanics and Engineering Science, Beijing 100871, China

Xiaoyun Jiang

Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China

Qiushi Ren

Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China

Changhui Li

Peking University, College of Engineering, Department of Biomedical Engineering, No. 5 Yiheyuan Road, Haidian, Beijing 100871, China

J. Biomed. Opt. 19(7), 076019 (Jul 28, 2014). doi:10.1117/1.JBO.19.7.076019
History: Received June 23, 2014; Revised July 4, 2014; Accepted July 9, 2014
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Abstract.  By allowing more photons to reach deeper tissue, the optical clearing agent (OCA) has gained increasing attention in various optical imaging modalities. However, commonly used OCAs have high fluidity, limiting their applications in in vivo studies with oblique, uneven, or moving surfaces. In this work, we reported an OCA with high viscosity. We measured the properties of this viscous OCA, and tested its successful performances in the imaging of a living animal’s skin with two optical imaging modalities: photoacoustic microscopy and optical coherence tomography. Our results demonstrated that the viscous OCA has a great potential in the study of different turbid tissues using various optical imaging modalities.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Zijian Deng ; Lijia Jing ; Ning Wu ; Pengyu lv ; Xiaoyun Jiang, et al.
"Viscous optical clearing agent for in vivo optical imaging", J. Biomed. Opt. 19(7), 076019 (Jul 28, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.7.076019


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