Research Papers: Imaging

Monitoring of interaction of low-frequency electric field with biological tissues upon optical clearing with optical coherence tomography

[+] Author Affiliations
Adrián F. Peña

University of Otago, The Jack Dodd Centre for Quantum Technology, Department of Physics, P.O. Box 56, Dunedin, 9054 New Zealand

Universidad Autónoma de Tamaulipas, Centro Universitario Tampico Madero, CP 89109, México

Alexander Doronin

University of Otago, The Jack Dodd Centre for Quantum Technology, Department of Physics, P.O. Box 56, Dunedin, 9054 New Zealand

Valery V. Tuchin

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov, 410012 Russia

Institute of Precise Mechanics and Control, Russian Academy of Science, Laboratory of Laser Diagnostics of Technical and Living Systems, 24 Rabochaya Street, Saratov, 410028 Russia

University of Oulu, Optoelectronics and Measurement Techniques Laboratory, P.O. Box 4500, Oulu, FI-90014, Finland

Igor Meglinski

University of Otago, The Jack Dodd Centre for Quantum Technology, Department of Physics, P.O. Box 56, Dunedin, 9054 New Zealand

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov, 410012 Russia

J. Biomed. Opt. 19(8), 086002 (Aug 06, 2014). doi:10.1117/1.JBO.19.8.086002
History: Received June 4, 2014; Revised July 13, 2014; Accepted July 14, 2014
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Abstract.  The influence of a low-frequency electric field applied to soft biological tissues ex vivo at normal conditions and upon the topical application of optical clearing agents has been studied by optical coherence tomography (OCT). The electro-kinetic response of tissues has been observed and quantitatively evaluated by the double correlation OCT approach, utilizing consistent application of an adaptive Wiener filtering and Fourier domain correlation algorithm. The results show that fluctuations, induced by the electric field within the biological tissues are exponentially increased in time. We demonstrate that in comparison to impedance measurements and the mapping of the temperature profile at the surface of the tissue samples, the double correlation OCT approach is much more sensitive to the changes associated with the tissues’ electro-kinetic response. We also found that topical application of the optical clearing agent reduces the tissues’ electro-kinetic response and is cooling the tissue, thus reducing the temperature induced by the electric current by a few degrees. We anticipate that dcOCT approach can find a new application in bioelectrical impedance analysis and monitoring of the electric properties of biological tissues, including the resistivity of high water content tissues and its variations.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Adrián F. Peña ; Alexander Doronin ; Valery V. Tuchin and Igor Meglinski
"Monitoring of interaction of low-frequency electric field with biological tissues upon optical clearing with optical coherence tomography", J. Biomed. Opt. 19(8), 086002 (Aug 06, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.8.086002


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