Research Papers: Sensing

Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix

[+] Author Affiliations
Vidita Urboniene, Milda Pucetaite, Valdas Sablinskas

Vilnius University, Department of General Physics and Spectroscopy, Sauletekio av. 9 bl. 3, Vilnius, LT-10234, Lithuania

Feliksas Jankevicius, Arunas Zelvys

Vilnius University, Urology Center, Santariskiu Str. 2, LT-08661 Vilnius, Lithuania

Gerald Steiner

Vilnius University, Department of General Physics and Spectroscopy, Sauletekio av. 9 bl. 3, Vilnius, LT-10234, Lithuania

Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus, Klinisches Sensoring und Monitoring, Fetscher Str. 74, 01307 Dresden, Germany

J. Biomed. Opt. 19(8), 087005 (Aug 20, 2014). doi:10.1117/1.JBO.19.8.087005
History: Received April 20, 2014; Revised July 8, 2014; Accepted July 17, 2014
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Abstract.  Fourier transform infrared (FT-IR) spectroscopy was applied to characterize the extracellular matrix (ECM) of kidney tumor tissue and normal kidney tissue. Freshly resected tissue samples from 31 patients were pressed on a CaF2 substrate. FT-IR spectra obtained from ECM of tumor tissue exhibit stronger absorption bands in the spectral region from 1000 to 1200cm1 and around 1750cm1 than those obtained from normal tissue. It is likely that the spectra of ECM of kidney tumor tissue with large increases in the intensities of these bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in the spectra of ECM from normal tissue, indicating a higher level of proteins. Our results suggest that FT-IR spectroscopy of the ECM is an innovative emerging technology for real-time intraoperative tumor diagnosis, which may improve margin clearance in renal cancer surgery.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Vidita Urboniene ; Milda Pucetaite ; Feliksas Jankevicius ; Arunas Zelvys ; Valdas Sablinskas, et al.
"Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix", J. Biomed. Opt. 19(8), 087005 (Aug 20, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.8.087005


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