Research Papers: Imaging

Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks

[+] Author Affiliations
Yong Zhou, Wenxin Xing, Song Hu, Konstantin I. Maslov, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, United States

Xiaobin Yi

Washington University School of Medicine, Department of Anesthesiology/Pain Management, 660 South Euclid Avenue, Campus Box 8054, St. Louis, Missouri 63110, United States

J. Biomed. Opt. 19(8), 086017 (Aug 21, 2014). doi:10.1117/1.JBO.19.8.086017
History: Received June 5, 2014; Revised August 1, 2014; Accepted August 1, 2014
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Abstract.  Complex regional pain syndrome (CRPS) is a chronic pain syndrome that causes intractable pain, disability, and poor quality of life for patients. The etiology and pathophysiology of CRPS are still poorly understood. Due to a lack of proper diagnostic tools, the prognosis of CRPS is primarily based on clinical observation. The objective of this work is to evaluate a new imaging modality, photoacoustic microscopy (PAM), for assisting diagnoses and monitoring the progress and treatment outcome of CRPS. Blood vasculature and oxygen saturation (sO2) were imaged by PAM from eight adult patients with CRPS-1. Patients’ hands and cuticles were imaged both before and after stellate ganglion block (SGB) for comparison. For all patients, both vascular structure and sO2 could be assessed by PAM. In addition, more vessels and stronger signals were observed after SGB. The results show that PAM can help diagnose and monitor CRPS.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Yong Zhou ; Xiaobin Yi ; Wenxin Xing ; Song Hu ; Konstantin I. Maslov, et al.
"Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks", J. Biomed. Opt. 19(8), 086017 (Aug 21, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.8.086017


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