Research Papers: Therapeutic

Preclinical investigations of articular cartilage ablation with femtosecond and pulsed infrared lasers as an alternative to microfracture surgery

[+] Author Affiliations
Erica Su

University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92612, United States

Hui Sun

Chinese Academy of Science, Academy of Opto-Electronics, Beijing 100094, China

Tibor Juhasz

University of California, Department of Biomedical Engineering, Irvine, California 92697, United States

Brian J. F. Wong

University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92612, United States

J. Biomed. Opt. 19(9), 098001 (Sep 08, 2014). doi:10.1117/1.JBO.19.9.098001
History: Received February 3, 2014; Revised August 16, 2014; Accepted August 19, 2014
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Abstract.  Microfracture surgery is a bone marrow stimulation technique for treating cartilage defects and injuries in the knee. Current methods rely on surgical skill and instrumentation. This study investigates the potential use of laser technology as an alternate means to create the microfracture holes. Lasers investigated in this study include an erbium:YAG laser (λ=2.94μm), titanium:sapphire femtosecond laser system (λ=1700nm), and Nd:glass femtosecond laser (λ=1053nm). Bovine samples were ablated at fluences of 8 to 18J/cm2 with the erbium:YAG laser, at a power of 300±15mW with the titanium:sapphire femtosecond system, and at an energy of 3μJ/pulse with the Nd:glass laser. Samples were digitally photographed and histological sections were taken for analysis. The erbium:YAG laser is capable of fast and efficient ablation; specimen treated with fluences of 12 and 18J/cm2 experienced significant amounts of bone removal and minimal carbonization with saline hydration. The femtosecond laser systems successfully removed cartilage but not clinically significant amounts of bone. Precise tissue removal was possible but not to substantial depths due to limitations of the systems. With additional studies and development, the use of femtosecond laser systems to ablate bone may be achieved at clinically valuable ablation rates.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Erica Su ; Hui Sun ; Tibor Juhasz and Brian J. F. Wong
"Preclinical investigations of articular cartilage ablation with femtosecond and pulsed infrared lasers as an alternative to microfracture surgery", J. Biomed. Opt. 19(9), 098001 (Sep 08, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.9.098001


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