Research Papers: Imaging

Continuous monitoring of arthritis in animal models using optical imaging modalities

[+] Author Affiliations
Taeyoon Son, Byungjo Jung

Yonsei University, Department of Biomedical Engineering, 1 Yonseidae-gil, Wonju, Gangwon-do 220-710, Republic of Korea

Hyung-Ju Yoon, Saseong Lee

Catholic University of Korea, Department of Internal Medicine, Research Institute of Immunobiology, 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea

Won Seuk Jang

Yonsei University, Department of Radiological Science, 1 Yonseidae-gil, Wonju, Gangwon-do 220-710, Republic of Korea

Wan-Uk Kim

Catholic University of Korea, Department of Internal Medicine, Research Institute of Immunobiology, 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea

Catholic University of Korea, Seoul St. Mary’s Hospital, Department of Internal Medicine, Division of Rheumatology, College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea

J. Biomed. Opt. 19(10), 106010 (Oct 23, 2014). doi:10.1117/1.JBO.19.10.106010
History: Received April 28, 2014; Revised August 19, 2014; Accepted September 11, 2014
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Abstract.  Given the several difficulties associated with histology, including difficulty in continuous monitoring, this study aimed to investigate the feasibility of optical imaging modalities—cross-polarization color (CPC) imaging, erythema index (EI) imaging, and laser speckle contrast (LSC) imaging—for continuous evaluation and monitoring of arthritis in animal models. C57BL/6 mice, used for the evaluation of arthritis, were divided into three groups: arthritic mice group (AMG), positive control mice group (PCMG), and negative control mice group (NCMG). Complete Freund’s adjuvant, mineral oil, and saline were injected into the footpad for AMG, PCMG, and NCMG, respectively. LSC and CPC images were acquired from 0 through 144 h after injection for all groups. EI images were calculated from CPC images. Variations in feet area, EI, and speckle index for each mice group over time were calculated for quantitative evaluation of arthritis. Histological examinations were performed, and the results were found to be consistent with those from optical imaging analysis. Thus, optical imaging modalities may be successfully applied for continuous evaluation and monitoring of arthritis in animal models.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Taeyoon Son ; Hyung-Ju Yoon ; Saseong Lee ; Won Seuk Jang ; Byungjo Jung, et al.
"Continuous monitoring of arthritis in animal models using optical imaging modalities", J. Biomed. Opt. 19(10), 106010 (Oct 23, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.10.106010


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