Research Papers: General

Feasibility study on photoacoustic guidance for high-intensity focused ultrasound-induced hemostasis

[+] Author Affiliations
Van Phuc Nguyen

Pukyong National University, Interdisciplinary Program of Marine-Bio, Department of Electrical and Mechanical Engineering, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of Korea

Jeehyun Kim

Kyungpook National University, School of Electrical Engineering and Computer Science, 80 Daehakro, Bukgu, Daegu 702-701, Republic of Korea

Kang-lyeol Ha

Pukyong National University, Department of Physics, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of Korea

Junghwan Oh, Hyun Wook Kang

Pukyong National University, Interdisciplinary Program of Marine-Bio, Department of Electrical and Mechanical Engineering, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of Korea

Pukyong National University, Center for Marine-Integrated Biomedical Technology (BK 21 Plus), Department of Biomedical Engineering, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of Korea

J. Biomed. Opt. 19(10), 105010 (Oct 29, 2014). doi:10.1117/1.JBO.19.10.105010
History: Received June 4, 2014; Revised September 15, 2014; Accepted September 23, 2014
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Abstract.  The feasibility of photoacoustic imaging (PAI) application was evaluated to map punctured blood vessels thermally treated by high-intensity focused ultrasound (HIFU) for hemostasis. A single-element HIFU transducer with a central frequency of 2.0 MHz, was used to induce thermal hemostasis on the punctured arteries. The HIFU-treated lesion was imaged and localized by high-contrast PAI guidance. The results showed that complete hemostasis was achieved after treatment of the damaged blood vessels within 25 to 52 s at the acoustic intensity of 3600W/cm2. The coagulation time for the animal artery was 20% longer than that of the phantom possibly due to a lower Young’s modulus. The reconstructed PA images were able to distinguish the treated area from the surrounding tissue in terms of augmented signal amplitudes (up to three times). Spectroscopic studies demonstrated that the optimal imaging wavelength was found to be 700 nm in order to reconstruct high-contrast photoacoustic images on HIFU-treated lesions. The proposed PAI integrated with HIFU treatment can be a feasible application to obtain safe and rapid hemostasis for acute arterial bleeding.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Van Phuc Nguyen ; Jeehyun Kim ; Kang-lyeol Ha ; Junghwan Oh and Hyun Wook Kang
"Feasibility study on photoacoustic guidance for high-intensity focused ultrasound-induced hemostasis", J. Biomed. Opt. 19(10), 105010 (Oct 29, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.10.105010


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