Research Papers: Imaging

Super-resolution photoacoustic microscopy using photonic nanojets: a simulation study

[+] Author Affiliations
Paul Kumar Upputuri

Nanyang Technological University, School of Chemical and Biomedical Engineering, Biomedical Imaging Laboratory, 70 Nanyang Drive, Singapore 637457, Singapore

Zhuo-Bin Wen

University of Electronic Science and Technology of China, School of Physical Electronics, National Laboratory for Vacuum Electronics, Chengdu 610054, China

Zhe Wu

University of Electronic Science and Technology of China, School of Physical Electronics, National Laboratory for Vacuum Electronics, Chengdu 610054, China

Manojit Pramanik

Nanyang Technological University, School of Chemical and Biomedical Engineering, Biomedical Imaging Laboratory, 70 Nanyang Drive, Singapore 637457, Singapore

J. Biomed. Opt. 19(11), 116003 (Nov 03, 2014). doi:10.1117/1.JBO.19.11.116003
History: Received August 11, 2014; Revised September 30, 2014; Accepted October 6, 2014
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Abstract.  Optical resolution photoacoustic microscopy (ORPAM) is important for various biomedical applications, such as the study of cellular structures, microcirculation systems, and tumor angiogenesis. However, the lateral resolution of a conventional ORPAM is limited by optical diffraction. In this work, we report a simulation study to achieve subdiffraction-limited super-resolution in ORPAM using microspheres. Laser radiation is focused through a microsphere to generate a photonic nanojet, which provides the possibility to break the diffraction limit in ORPAM by reducing the size of the excitation volume. In our simulations using microspheres, we observed improvement in the lateral resolution up to fourfold compared to conventional ORPAM. The method is simple, cost effective, and can provide far-field resolution. This approach may provide new opportunities for many biomedical imaging applications that require finer resolution.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Paul Kumar Upputuri ; Zhuo-Bin Wen ; Zhe Wu and Manojit Pramanik
"Super-resolution photoacoustic microscopy using photonic nanojets: a simulation study", J. Biomed. Opt. 19(11), 116003 (Nov 03, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.11.116003


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