Ultrasound-based imaging techniques have shown to increase the diagnostic yield by helping the radiologist to more precisely place the needle within the suspicious mass.8,9 Improved diagnosis and early detection of cancer could spare patients from more invasive and traumatizing surgical procedures. However, in addition to proper needle placement, several factors can impact the success of the biopsy. Such factors include tumor heterogeneity, which results in sampling errors, suboptimal preparation of the cytology/histology slides, and limited experience of the radiologist and cytopathologist. In particular, tumor heterogeneity plays an important role in biopsy yield.10,11 Tumors can have varying degrees of necrosis, fibrosis, and tissue repair admixed with tumor tissue. These additional tissue types negatively impact the diagnostic yield. For example, the aspiration of the nonviable area of the tumor results in a nondiagnostic FNAB in about 20% of the cases.3 Therefore, acquiring adequate aspirate material that can be used for cytologic interpretation remains challenging. Needle placement in a cancer-rich environment would substantially reduce the number of nondiagnostic aspirates and, therefore, the frequency of repeated biopsies. Although nonoptical image-guidance modalities, such as CT or ultrasound, help to see a mass distinct from the normal breast tissue, their limited resolution does not allow identifying tissue cellularity, which is defined as the composition of the tissue with regards to the categories of constituent cells.