Research Papers: Sensing

Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution

[+] Author Affiliations
Edoardo Gino Macchi

Università di Pavia, Dipartimento di Ingegneria Civile ed Architettura, via Ferrata 3, 27100 Pavia (PV), Italy

Daniele Tosi

University of Limerick, Optical Fibre Sensors Research Centre, Plassey House, Limerick, Ireland

Giovanni Braschi

Università di Pavia, Dipartimento di Ingegneria Civile ed Architettura, via Ferrata 3, 27100 Pavia (PV), Italy

Mario Gallati

Università di Pavia, Dipartimento di Ingegneria Civile ed Architettura, via Ferrata 3, 27100 Pavia (PV), Italy

Alfredo Cigada

Politecnico di Milano, Dipartimento di Meccanica, via La Masa 34, 20158 Milano (MI), Italy

Giorgio Busca

Politecnico di Milano, Dipartimento di Meccanica, via La Masa 34, 20158 Milano (MI), Italy

Elfed Lewis

University of Limerick, Optical Fibre Sensors Research Centre, Plassey House, Limerick, Ireland

J. Biomed. Opt. 19(11), 117004 (Nov 11, 2014). doi:10.1117/1.JBO.19.11.117004
History: Received July 14, 2014; Revised October 6, 2014; Accepted October 8, 2014
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Abstract.  Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6°C/mm) and temporal (up to 1°C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Edoardo Gino Macchi ; Daniele Tosi ; Giovanni Braschi ; Mario Gallati ; Alfredo Cigada, et al.
"Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution", J. Biomed. Opt. 19(11), 117004 (Nov 11, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.11.117004


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