Research Papers: Therapeutic

Laser-induced microjet injection into preablated skin for more effective transdermal drug delivery

[+] Author Affiliations
Hun-jae Jang, Jack J. Yoh

Seoul National University, Department of Mechanical and Aerospace Engineering, 1 Gwanakro, Gwanakgu, Seoul 151-742, Republic of Korea

Eugene Hur, Yoonkwan Kim, Seol-Hoon Lee, Nae G. Kang

LG Household & Health Care R&D Center, 84 Jang-dong, Yuseong-gu, Daejeon 305-343, Republic of Korea

J. Biomed. Opt. 19(11), 118002 (Nov 18, 2014). doi:10.1117/1.JBO.19.11.118002
History: Received June 16, 2014; Accepted October 22, 2014
Text Size: A A A

Abstract.  A breakthrough in the efficient transdermal delivery of drug via the laser-driven microjet is reported. A single source of laser beam is split into two: one beam ablates a targeted spot on a skin and another beam drives the injector for fast microjet ejection into a preablated spot. This combined ablation and microjet injection scheme using a beam splitter utilizes 14 laser energy sharing between generation of the microhole via ablation and the microjet which is generated using the Er:YAG laser beam at a 2940-nm wavelength and 150-μs pulse duration. A careful analysis of the injection mechanism is carried out by studying the response of the elastic membrane that separates a driving water unit for bubble expansion from a drug unit for a microjet ejection. The efficiency of the present delivery scheme is evaluated by the abdominal porcine skin test using the fluorescein isothiocyanate staining and the confocal microscopy for quantitative delivery confirmation. The depth of penetration and the injected volume of the drug are also confirmed by polyacrylamide gel tests.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Hun-jae Jang ; Eugene Hur ; Yoonkwan Kim ; Seol-Hoon Lee ; Nae G. Kang, et al.
"Laser-induced microjet injection into preablated skin for more effective transdermal drug delivery", J. Biomed. Opt. 19(11), 118002 (Nov 18, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.11.118002


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.