The carotid artery (CA) supplies the brain with oxygenated blood. A healthy CA consists of elastic collagen-rich material, allowing it to sustain large and rapid variations in blood pressure. A CA affected by atherosclerosis shows degradation of the collagen structure, thickening of the intima, and formation of complex plaques that contain regions with a lipid-rich necrotic core, calcifications, and often intraplaque hemorrhage. Such vulnerable plaques may rupture and cause cerebral ischemic events.1 The CA is easily accessible for noninvasive imaging, making it a viable target for the screening of a population at risk for cardiovascular or cerebrovascular events.2 Common imaging modalities used for CA screening are ultrasound (US), x-ray computed tomography (CT), and magnetic resonance imaging. These techniques provide mostly morphological information, such as vessel wall thickening, accumulation of atherosclerosis, and luminal narrowing. They, however, lack the capability of providing chemically specific information crucial in the clinical evaluation of CA.3 There is an unmet clinical need for a diagnostic technique that can improve risk stratification based on CA plaque characteristics. In the variable composition of atherosclerotic tissue, several plaque lipids have been identified that are associated with vulnerability.4 Noninvasive imaging of CA plaque lipidomics may better assess the risk of future events to inform medical or surgical therapeutic strategies.