Errata

Errata: Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography

[+] Author Affiliations
Dolonchampa Maji, Metasebya Solomon, Samuel Achilefu, Joseph P. Culver

Washington University, Department of Biomedical Engineering, One Brookings Drive, St. Louis, Missouri 63110, United States

Washington University School of Medicine, Department of Radiology, 4525 Scott Avenue, St. Louis, Missouri 63110, United States

Annie Nguyen, Richard A. Pierce, Dana R. Abendschein

Washington University School of Medicine, Center for Cardiovascular Research, Department of Internal Medicine, 660 S. Euclid Avenue, St. Louis, Missouri 63110, United States

Pamela K. Woodard, Walter J. Akers, Monica Shokeen

Washington University School of Medicine, Department of Radiology, 4525 Scott Avenue, St. Louis, Missouri 63110, United States

J. Biomed. Opt. 19(11), 119801 (Nov 26, 2014). doi:10.1117/1.JBO.19.11.119801
History:
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This article [J. Biomed. Opt.. 19, (11 ), 110501  (2014)] was originally published online on 12 November 2014 with errors in the three figure captions. The figures and corrected captions are republished below.

Figures in this Article

Graphic Jump LocationF1 :

(a) Absorption and fluorescence spectra of LS668 in dimethylsulfoxide. Fluorescence microscopy images showing cellular internalization of LS668 (b) in NPR-C transfected cells, (c) inhibition of inter- nalization in presence of excess C-ANF peptide, and (d) absence of internalization in NPR-A transfected cells. Blue (DAPI, nuclear stain) and red (LS668). Scale: 100μm.

Graphic Jump LocationF2 :

(a) Coronal (depth=7mm), sagittal and transverse sections of reconstructed fluorescence molecular tomography (FMT) signal from injured artery and corresponding control artery from a representative animal (rabbit 1). White lines indicate the position of the respective sagittal and transverse sections. (b) Schematic showing the relationship between the FMT images displayed to their orientation with respect to the tissue volume. (c) Time dependent changes in integrated fluorescence signal (mean±SD, n=3) for injured and control arteries (*P=0.0283; **P=0.0282). (d) Mean (n=2) fluorescence intensity obtained from the ex vivo injured artery containing the lesion and the control artery. Adjoining figure (inset) shows the fluorescence images (excitation/emission: 785nm/>800nm) of the injured artery containing the lesion (top) and the control artery (bottom).

Graphic Jump LocationF3 :

Ex vivo studies on the paraffin fixed sections of injured (top row) and control artery (bottom row) sections obtained at 8 weeks post-surgery. (a) Bright field images showing IEL, internal elastic lamina; A, adventitia; M, media; 1 deg NEO: primary neointima. Scale: 500μm. (b) Corresponding fluorescence images (excitation/emission: 710±75nm/810±90nm) after ex vivo staining with LS668. Scale: 500μm. (c) Immunohistochemistry on tissue sections with clone RAM11 antibody (1: 100 dilution; blue) for macrophages and counterstained with nuclear fast red. Scale: 250μm.

This article was corrected online on 14 November 2014. It appears correctly in print.

© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation

Dolonchampa Maji ; Metasebya Solomon ; Annie Nguyen ; Richard A. Pierce ; Pamela K. Woodard, et al.
"Errata: Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography", J. Biomed. Opt. 19(11), 119801 (Nov 26, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.11.119801


Figures

Graphic Jump LocationF1 :

(a) Absorption and fluorescence spectra of LS668 in dimethylsulfoxide. Fluorescence microscopy images showing cellular internalization of LS668 (b) in NPR-C transfected cells, (c) inhibition of inter- nalization in presence of excess C-ANF peptide, and (d) absence of internalization in NPR-A transfected cells. Blue (DAPI, nuclear stain) and red (LS668). Scale: 100μm.

Graphic Jump LocationF2 :

(a) Coronal (depth=7mm), sagittal and transverse sections of reconstructed fluorescence molecular tomography (FMT) signal from injured artery and corresponding control artery from a representative animal (rabbit 1). White lines indicate the position of the respective sagittal and transverse sections. (b) Schematic showing the relationship between the FMT images displayed to their orientation with respect to the tissue volume. (c) Time dependent changes in integrated fluorescence signal (mean±SD, n=3) for injured and control arteries (*P=0.0283; **P=0.0282). (d) Mean (n=2) fluorescence intensity obtained from the ex vivo injured artery containing the lesion and the control artery. Adjoining figure (inset) shows the fluorescence images (excitation/emission: 785nm/>800nm) of the injured artery containing the lesion (top) and the control artery (bottom).

Graphic Jump LocationF3 :

Ex vivo studies on the paraffin fixed sections of injured (top row) and control artery (bottom row) sections obtained at 8 weeks post-surgery. (a) Bright field images showing IEL, internal elastic lamina; A, adventitia; M, media; 1 deg NEO: primary neointima. Scale: 500μm. (b) Corresponding fluorescence images (excitation/emission: 710±75nm/810±90nm) after ex vivo staining with LS668. Scale: 500μm. (c) Immunohistochemistry on tissue sections with clone RAM11 antibody (1: 100 dilution; blue) for macrophages and counterstained with nuclear fast red. Scale: 250μm.

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