Special Section on Laser Applications in Life Sciences

Assessment of colloid response by nonlinear optical microscopy after preoperative radiochemotherapy for rectal carcinoma

[+] Author Affiliations
Lianhuang Li, Shuangmu Zhuo, Hongsheng Li, Jianxin Chen

Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou 350007, China

Zhifen Chen, Weizhong Jiang, Guoxian Guan

Fujian Medical University, The Affiliated Union Hospital, Department of Colorectal Surgery, Fuzhou 350001, China

Xingfu Wang

Fujian Medical University, The First Affiliated Hospital, Department of Pathology, Fuzhou 350001, China

J. Biomed. Opt. 20(5), 051009 (Dec 01, 2014). doi:10.1117/1.JBO.20.5.051009
History: Received August 23, 2014; Accepted October 27, 2014
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Abstract.  Colloid response is a type of tumor response that occurs after preoperative radiochemotherapy for rectal carcinoma. Given its important influence on survival, the colloid response should be considered when estimating histopathological reactions. Here, multiphoton microscopy (MPM) was applied to evaluate the colloid response ex vivo. This study demonstrated that MPM has the capability to visualize the colloid response in the absence of labels and can, in particular, identify rare residual carcinomatous cells in mucin pools. These results highlight the potential of this nonlinear optical technique as a diagnostic tool for tumor response after neoadjuvant treatment.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Lianhuang Li ; Zhifen Chen ; Xingfu Wang ; Shuangmu Zhuo ; Hongsheng Li, et al.
"Assessment of colloid response by nonlinear optical microscopy after preoperative radiochemotherapy for rectal carcinoma", J. Biomed. Opt. 20(5), 051009 (Dec 01, 2014). ; http://dx.doi.org/10.1117/1.JBO.20.5.051009


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