Research Papers: Imaging

Volumetric full-range magnetomotive optical coherence tomography

[+] Author Affiliations
Adeel Ahmad

University of Illinois at Urbana–Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, United States

University of Illinois at Urbana–Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois 61801, United States

Jongsik Kim

University of Illinois at Urbana–Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, United States

Nathan D. Shemonski

University of Illinois at Urbana–Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, United States

University of Illinois at Urbana–Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois 61801, United States

Marina Marjanovic

University of Illinois at Urbana–Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, United States

Stephen A. Boppart

University of Illinois at Urbana–Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, United States

University of Illinois at Urbana–Champaign, Department of Electrical and Computer Engineering, Urbana, Illinois 61801, United States

University of Illinois at Urbana–Champaign, Department of Bioengineering, Urbana, Illinois 61801, United States

University of Illinois at Urbana–Champaign, Department of Internal Medicine, Urbana, Illinois 61801, United States

J. Biomed. Opt. 19(12), 126001 (Dec 03, 2014). doi:10.1117/1.JBO.19.12.126001
History: Received August 3, 2014; Accepted October 16, 2014
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Abstract.  Magnetomotive optical coherence tomography (MM-OCT) can be utilized to spatially localize the presence of magnetic particles within tissues or organs. These magnetic particle-containing regions are detected by using the capability of OCT to measure small-scale displacements induced by the activation of an external electromagnet coil typically driven by a harmonic excitation signal. The constraints imposed by the scanning schemes employed and tissue viscoelastic properties limit the speed at which conventional MM-OCT data can be acquired. Realizing that electromagnet coils can be designed to exert MM force on relatively large tissue volumes (comparable or larger than typical OCT imaging fields of view), we show that an order-of-magnitude improvement in three-dimensional (3-D) MM-OCT imaging speed can be achieved by rapid acquisition of a volumetric scan during the activation of the coil. Furthermore, we show volumetric (3-D) MM-OCT imaging over a large imaging depth range by combining this volumetric scan scheme with full-range OCT. Results with tissue equivalent phantoms and a biological tissue are shown to demonstrate this technique.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Adeel Ahmad ; Jongsik Kim ; Nathan D. Shemonski ; Marina Marjanovic and Stephen A. Boppart
"Volumetric full-range magnetomotive optical coherence tomography", J. Biomed. Opt. 19(12), 126001 (Dec 03, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.12.126001


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