Research Papers: Imaging

Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking

[+] Author Affiliations
Peijun Gong

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Lixin Chin

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Shaghayegh Es’haghian

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Yih Miin Liew

University of Malaya, Faculty of Engineering, Department of Biomedical Engineering, Kuala Lumpur 50603, Malaysia

Fiona M. Wood

Royal Perth Hospital, Burns Service of Western Australia, Wellington Street, Perth, Western Australia 6000, Australia

The University of Western Australia, School of Surgery, Burn Injury Research Unit, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.

David D. Sampson

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

The University of Western Australia, Centre for Microscopy, Characterisation and Analysis, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Robert A. McLaughlin

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 19(12), 126014 (Dec 24, 2014). doi:10.1117/1.JBO.19.12.126014
History: Received July 18, 2014; Accepted November 3, 2014
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Abstract.  We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2±0.2 (mean±standard deviation), while the ratio of birefringence of normotrophic scars to normal skin is 1.1±0.4. This method represents a new clinically applicable means for objective, quantitative human scar assessment.

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© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Peijun Gong ; Lixin Chin ; Shaghayegh Es’haghian ; Yih Miin Liew ; Fiona M. Wood, et al.
"Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking", J. Biomed. Opt. 19(12), 126014 (Dec 24, 2014). ; http://dx.doi.org/10.1117/1.JBO.19.12.126014


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