Research Papers: Imaging

Swept source optical coherence tomography Gabor fusion splicing technique for microscopy of thick samples using a deformable mirror

[+] Author Affiliations
Christopher Costa, Adrian Bradu, John Rogers, Adrian Podoleanu

University of Kent, School of Physical Sciences, Applied Optics Group, Canterbury CT2 7NZ, United Kingdom

Pauline Phelan

University of Kent, School of BioSciences, Cell Biology, Cancer Targets and Therapies Group, Canterbury CT2 7NZ, United Kingdom

J. Biomed. Opt. 20(1), 016012 (Jan 14, 2015). doi:10.1117/1.JBO.20.1.016012
History: Received April 28, 2014; Accepted December 2, 2014
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Abstract.  We present a swept source optical coherence tomography (OCT) system at 1060 nm equipped with a wavefront sensor at 830 nm and a deformable mirror in a closed-loop adaptive optics (AO) system. Due to the AO correction, the confocal profile of the interface optics becomes narrower than the OCT axial range, restricting the part of the B-scan (cross section) with good contrast. By actuating on the deformable mirror, the depth of the focus is changed and the system is used to demonstrate Gabor filtering in order to produce B-scan OCT images with enhanced sensitivity throughout the axial range from a Drosophila larvae. The focus adjustment is achieved by manipulating the curvature of the deformable mirror between two user-defined limits. Particularities of controlling the focus for Gabor filtering using the deformable mirror are presented.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Christopher Costa ; Adrian Bradu ; John Rogers ; Pauline Phelan and Adrian Podoleanu
"Swept source optical coherence tomography Gabor fusion splicing technique for microscopy of thick samples using a deformable mirror", J. Biomed. Opt. 20(1), 016012 (Jan 14, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.016012


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