Research Papers: Imaging

Optical palpation in vivo: imaging human skin lesions using mechanical contrast

[+] Author Affiliations
Shaghayegh Es’haghian

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Kelsey M. Kennedy

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Peijun Gong

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

David D. Sampson

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

The University of Western Australia, Centre for Microscopy, Characterisation and Analysis, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Robert A. McLaughlin

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Brendan F. Kennedy

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical+Biomedical Engineering Laboratory, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 20(1), 016013 (Jan 14, 2015). doi:10.1117/1.JBO.20.1.016013
History: Received September 29, 2014; Accepted December 4, 2014
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Abstract.  We demonstrate the first application of the recently proposed method of optical palpation to in vivo imaging of human skin. Optical palpation is a tactile imaging technique that probes the spatial variation of a sample’s mechanical properties by producing an en face map of stress measured at the sample surface. This map is determined from the thickness of a translucent, compliant stress sensor placed between a loading element and the sample and is measured using optical coherence tomography. We assess the performance of optical palpation using a handheld imaging probe on skin-mimicking phantoms, and demonstrate its use on human skin lesions. Our results demonstrate the capacity of optical palpation to delineate the boundaries of lesions and to map the mechanical contrast between lesions and the surrounding normal skin.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Shaghayegh Es’haghian ; Kelsey M. Kennedy ; Peijun Gong ; David D. Sampson ; Robert A. McLaughlin, et al.
"Optical palpation in vivo: imaging human skin lesions using mechanical contrast", J. Biomed. Opt. 20(1), 016013 (Jan 14, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.016013


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