JBO Letters

Noninvasive diagnosis and therapeutic effect evaluation of deep vein thrombosis in clinics by near-infrared spectroscopy

[+] Author Affiliations
Ting Li, Yunlong Sun, Xiao Chen, Yue Zhao

University of Electronic Science and Technology of China, State Key Lab of Electronic Thin Films and Integrated Devices, Biomedical Engineering Department, Sec.2, No.4 Jianshe north road, Chengdu 610054, China

Rongrong Ren

Xinhua Hospital, Department of Anesthesiology and Surgical Intensive Care Unit, 1665 Kongjiang road, Shanghai 200092, China

J. Biomed. Opt. 20(1), 010502 (Jan 20, 2015). doi:10.1117/1.JBO.20.1.010502
History: Received October 15, 2014; Accepted December 30, 2014
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Abstract.  Deep vein thrombosis (DVT) has become a severe disease with a rising incidence rate. The conventional diagnosis relies on complicated imaging modalities that may also involve invasive contrast agent injection and ionizing procedures (e.g., venography). Noninvasive near-infrared spectroscopy (NIRS) methods have been explored which required the DVT patients to follow some exercise protocols. Here, we attempt to use portable NIRS under patients’ natural state for DVT diagnosis. Nine DVT patients and seven healthy subjects participated in NIRS measurements of concentration of oxy- and deoxy-hemoglobins (Δ[HbO2] and Δ[Hb]) relative to data on a tissue mimicking phantom at six particular sites of calves. It was found that Δ[HbO2] is significantly lower in DVT patients than healthy ones, whereas Δ[Hb] is distinctly higher. Moreover, after thrombolytic therapy, both Δ[HbO2] and Δ[Hb] in DVT calves assume a gradual convergence to the curves of healthy ones. This reveals the potential of NIRS for the noninvasive, continuous, and straightforward monitoring/therapeutic effect evaluation of DVT in clinics with appropriate bedside monitoring capability.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Ting Li ; Yunlong Sun ; Xiao Chen ; Yue Zhao and Rongrong Ren
"Noninvasive diagnosis and therapeutic effect evaluation of deep vein thrombosis in clinics by near-infrared spectroscopy", J. Biomed. Opt. 20(1), 010502 (Jan 20, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.010502


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