Research Papers: Imaging

Multimodal imaging of cutaneous wound tissue

[+] Author Affiliations
Shiwu Zhang, Ronald Xu

University of Science and Technology of China, School of Engineering Science, Hefei 230026, China

The Ohio State University, Department of Biomedical Engineering, Columbus, Ohio 43210, United States

Surya Gnyawali, Gayle Gordillo, Chandan K. Sen

The Ohio State University, Department of Surgery, Columbus, Ohio 43210, United States

Jiwei Huang

The Ohio State University, Department of Biomedical Engineering, Columbus, Ohio 43210, United States

Wenqi Ren

University of Science and Technology of China, School of Engineering Science, Hefei 230026, China

J. Biomed. Opt. 20(1), 016016 (Jan 20, 2015). doi:10.1117/1.JBO.20.1.016016
History: Received September 5, 2014; Accepted December 8, 2014
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Abstract.  Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, few methods are available for simultaneous assessment of these tissue parameters in a noninvasive and quantitative fashion. We integrated hyperspectral, laser speckle, and thermographic imaging modalities in a single-experimental setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Algorithms were developed for appropriate coregistration between wound images acquired by different imaging modalities at different times. The multimodal wound imaging system was validated in an occlusion experiment, where oxygenation and perfusion maps of a healthy subject’s upper extremity were continuously monitored during a postocclusive reactive hyperemia procedure and compared with standard measurements. The system was also tested in a clinical trial where a wound of three millimeters in diameter was introduced on a healthy subject’s lower extremity and the healing process was continuously monitored. Our in vivo experiments demonstrated the clinical feasibility of multimodal cutaneous wound imaging.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Shiwu Zhang ; Surya Gnyawali ; Jiwei Huang ; Wenqi Ren ; Gayle Gordillo, et al.
"Multimodal imaging of cutaneous wound tissue", J. Biomed. Opt. 20(1), 016016 (Jan 20, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.016016


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