Research Papers: Imaging

Use of hyperspectral imaging technology to develop a diagnostic support system for gastric cancer

[+] Author Affiliations
Atsushi Goto

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

Jun Nishikawa

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

Shu Kiyotoki

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

Munetaka Nakamura

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

Junichi Nishimura

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

Takeshi Okamoto

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

Hiroyuki Ogihara

Yamaguchi University Graduate School of Medicine, Department of Biomolecular Engineering, Tokiwadai 2-16-1, Ube, Yamaguchi 755-8611, Japan

Yusuke Fujita

Yamaguchi University Graduate School of Medicine, Department of Biomolecular Engineering, Tokiwadai 2-16-1, Ube, Yamaguchi 755-8611, Japan

Yoshihiko Hamamoto

Yamaguchi University Graduate School of Medicine, Department of Biomolecular Engineering, Tokiwadai 2-16-1, Ube, Yamaguchi 755-8611, Japan

Isao Sakaida

Yamaguchi University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan

J. Biomed. Opt. 20(1), 016017 (Jan 20, 2015). doi:10.1117/1.JBO.20.1.016017
History: Received July 8, 2014; Accepted December 18, 2014
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Abstract.  Hyperspectral imaging (HSI) is a new technology that obtains spectroscopic information and renders it in image form. This study examined the difference in the spectral reflectance (SR) of gastric tumors and normal mucosa recorded with a hyperspectral camera equipped with HSI technology and attempted to determine the specific wavelength that is useful for the diagnosis of gastric cancer. A total of 104 gastric tumors removed by endoscopic submucosal dissection from 96 patients at Yamaguchi University Hospital were recorded using a hyperspectral camera. We determined the optimal wavelength and the cut-off value for differentiating tumors from normal mucosa to establish a diagnostic algorithm. We also attempted to highlight tumors by image processing using the hyperspectral camera’s analysis software. A wavelength of 770 nm and a cut-off value of 1/4 the corrected SR were selected as the respective optimal wavelength and cut-off values. The rates of sensitivity, specificity, and accuracy of the algorithm’s diagnostic capability were 71%, 98%, and 85%, respectively. It was possible to enhance tumors by image processing at the 770-nm wavelength. HSI can be used to measure the SR in gastric tumors and to differentiate between tumorous and normal mucosa.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Atsushi Goto ; Jun Nishikawa ; Shu Kiyotoki ; Munetaka Nakamura ; Junichi Nishimura, et al.
"Use of hyperspectral imaging technology to develop a diagnostic support system for gastric cancer", J. Biomed. Opt. 20(1), 016017 (Jan 20, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.016017


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