Research Papers: Imaging

Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system

[+] Author Affiliations
Shengkui Gao

Washington University in St. Louis, Computer Science and Engineering Department, St. Louis, Missouri 63130, United States

Suman B. Mondal

Washington University in St. Louis, Department of Radiology, St. Louis, Missouri 63130, United States

Nan Zhu

University of Arizona, College of Optical Sciences, Tucson, Arizona 85721, United States

RongGuang Liang

University of Arizona, College of Optical Sciences, Tucson, Arizona 85721, United States

Samuel Achilefu

Washington University in St. Louis, Department of Radiology, St. Louis, Missouri 63130, United States

Viktor Gruev

Washington University in St. Louis, Computer Science and Engineering Department, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 20(1), 016018 (Jan 20, 2015). doi:10.1117/1.JBO.20.1.016018
History: Received September 25, 2014; Accepted December 18, 2014
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Abstract.  Near infrared (NIR) fluorescence imaging has shown great potential for various clinical procedures, including intraoperative image guidance. However, existing NIR fluorescence imaging systems either have a large footprint or are handheld, which limits their usage in intraoperative applications. We present a compact NIR fluorescence imaging system (NFIS) with an image overlay solution based on threshold detection, which can be easily integrated with a goggle display system for intraoperative guidance. The proposed NFIS achieves compactness, light weight, hands-free operation, high-precision superimposition, and a real-time frame rate. In addition, the miniature and ultra-lightweight light-emitting diode tracking pod is easy to incorporate with NIR fluorescence imaging. Based on experimental evaluation, the proposed NFIS solution has a lower detection limit of 25 nM of indocyanine green at 27 fps and realizes a highly precise image overlay of NIR and visible images of mice in vivo. The overlay error is limited within a 2-mm scale at a 65-cm working distance, which is highly reliable for clinical study and surgical use.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Shengkui Gao ; Suman B. Mondal ; Nan Zhu ; RongGuang Liang ; Samuel Achilefu, et al.
"Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system", J. Biomed. Opt. 20(1), 016018 (Jan 20, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.016018


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