Research Papers: Imaging

In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography

[+] Author Affiliations
Li Lin

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States

Jun Xia

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States

The State University of New York, University at Buffalo, Department of Biomedical Engineering, Buffalo, New York 14260, United States

Terence T. W. Wong

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States

Lei Li

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States

Lihong V. Wang

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 20(1), 016019 (Jan 22, 2015). doi:10.1117/1.JBO.20.1.016019
History: Received November 3, 2014; Accepted January 6, 2015
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Abstract.  Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Li Lin ; Jun Xia ; Terence T. W. Wong ; Lei Li and Lihong V. Wang
"In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography", J. Biomed. Opt. 20(1), 016019 (Jan 22, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.016019


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