Research Papers: General

Photocontrolled nitric oxide release from two nitrosylruthenium isomer complexes and their potential biomedical applications

[+] Author Affiliations
Jiao Liu

Shanxi University, Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, 92 Wucheng Road, Taiyuan 030006, China

Qingqing Duan

Shanxi University, Institute of Opto-Electronics, State Key Lab of Quantum Optics and Quantum Optics Devices, 92 Wucheng Road, Taiyuan 030006, China

Jianru Wang

Shanxi University, Institute of Opto-Electronics, State Key Lab of Quantum Optics and Quantum Optics Devices, 92 Wucheng Road, Taiyuan 030006, China

Shanxi Medical University, Institute of Basic Medicine, 56 Xinjiannan Road, Taiyuan 030012, China

Zhen Song

Shanxi University, Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, 92 Wucheng Road, Taiyuan 030006, China

Xiaoyan Qiao

Shanxi University, College of Physics & Electronics Engineering, 92 Wucheng Road, Taiyuan 030006, China

Hongfei Wang

Shanxi University, Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, 92 Wucheng Road, Taiyuan 030006, China

Shanxi University, Institute of Opto-Electronics, State Key Lab of Quantum Optics and Quantum Optics Devices, 92 Wucheng Road, Taiyuan 030006, China

J. Biomed. Opt. 20(1), 015004 (Jan 26, 2015). doi:10.1117/1.JBO.20.1.015004
History: Received October 2, 2014; Accepted December 17, 2014
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Abstract.  Nitric oxide (NO) has key regulatory roles in various biological and medical processes. The control of its local concentration, which is crucial for obtaining the desired effect, can be achieved with exogenous NO donors. Release of NO from metal-nitrosyl complexes upon exposure to light is a strategy that could allow for the site-specific delivery of the reactive species NO to physiological targets. The photodissociation of NO from two nitrosylruthenium(II) isomer complexes {cis- and trans-[Ru(OAc)(2mqn)2NO]} was demonstrated by matrix-assisted laser desorption ionization time-of-flight mass spectrometry spectra, and electron paramagnetic resonance spectra further prove the photoinduced NO release by spin trapping of NO free radicals upon photoirradiation. Real-time NO release was quantitatively measured by electrochemistry with an NO-specific electrode. The quantitative control of NO release from [Ru(OAc)(2mqn)2NO] in aqueous solutions was done by photoirradiation at different wavelengths. Both isomers show photoinduced damage on plasmid DNA, but the trans isomer has higher cytotoxicity and photocytotoxicity activity against the HeLa tumor cell line than that of the cis isomer. Nitrosylruthenium(II) complex, with 8-quinolinol derivatives as ligands, has a great potential as a photoactivated NO donor reagent for biomedical applications.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Jiao Liu ; Qingqing Duan ; Jianru Wang ; Zhen Song ; Xiaoyan Qiao, et al.
"Photocontrolled nitric oxide release from two nitrosylruthenium isomer complexes and their potential biomedical applications", J. Biomed. Opt. 20(1), 015004 (Jan 26, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.1.015004


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