JBO Letters

Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation

[+] Author Affiliations
Zhaolong Han, Jiasong Li, Manmohan Singh, Chen Wu, Chih-hao Liu

University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States

Salavat R. Aglyamov

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, United States

Shang Wang, Kirill V. Larin

University of Houston, Department of Biomedical Engineering, Houston, Texas 77204, United States

Baylor College of Medicine, Department of Molecular Physiology and Biophysics, Houston, Texas 77030, United States

Srilatha Vantipalli

University of Houston, College of Optometry, Houston, Texas 77204, United States

Michael D. Twa

University of Alabama, School of Optometry, Birmingham, Alabama 35294, United States

J. Biomed. Opt. 20(2), 020501 (Feb 03, 2015). doi:10.1117/1.JBO.20.2.020501
History: Received October 31, 2014; Accepted January 9, 2015
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Abstract.  We demonstrate the use of a modified Rayleigh–Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young’s moduli of the samples using the Rayleigh–Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n=3) and then applied to porcine corneas (n=3) in situ. The Young’s moduli of the porcine corneas were estimated to be 60kPa with a shear viscosity 0.33Pa·s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Zhaolong Han ; Salavat R. Aglyamov ; Jiasong Li ; Manmohan Singh ; Shang Wang, et al.
"Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation", J. Biomed. Opt. 20(2), 020501 (Feb 03, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.2.020501


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