JBO Letters

Promotion of neural sprouting using low-level green light-emitting diode phototherapy

[+] Author Affiliations
Noa Alon, Hamootal Duadi, Ortal Cohen, Tamar Samet, Neta Zilony, Hadas Schori, Orit Shefi, Zeev Zalevsky

Bar-Ilan University, Faculty of Engineering and Institute of Nanotechnologies and Advanced Materials, Ramat-Gan 52900, Israel

J. Biomed. Opt. 20(2), 020502 (Feb 04, 2015). doi:10.1117/1.JBO.20.2.020502
History: Received November 12, 2014; Accepted December 23, 2014
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Abstract

Abstract.  We irradiated neuroblastoma SH-SY5Y cell line with low-level light-emitting diode (LED) illumination at a visible wavelength of 520 nm (green) and intensity of 100mW/cm2. We captured and analyzed the cell morphology before LED treatment, immediately after, and 12 and 24 h after treatment. Our study demonstrated that LED illumination increases the amount of sprouting dendrites in comparison to the control untreated cells. This treatment also resulted in more elongated cells after treatment in comparison to the control cells and higher levels of expression of a differentiation related gene. This result is a good indication that the proposed method could serve in phototherapy treatment for increasing sprouting and enhancing neural network formation.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Noa Alon ; Hamootal Duadi ; Ortal Cohen ; Tamar Samet ; Neta Zilony, et al.
"Promotion of neural sprouting using low-level green light-emitting diode phototherapy", J. Biomed. Opt. 20(2), 020502 (Feb 04, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.2.020502


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