Research Papers: General

Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers

[+] Author Affiliations
Valery P. Zakharov

Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia

Ivan A. Bratchenko

Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia

Dmitry N. Artemyev

Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia

Oleg O. Myakinin

Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia

Dmitry V. Kornilin

Samara State Aerospace University (SSAU), Department of Laser and Biotechnical Systems, 34 Moskovskoye shosse, Samara 443086, Russia

Sergey V. Kozlov

Samara State Medical University, Department of Oncology, 80 Polevaya Street, Samara 443099, Russia

Alexander A. Moryatov

Samara State Medical University, Department of Oncology, 80 Polevaya Street, Samara 443099, Russia

J. Biomed. Opt. 20(2), 025003 (Feb 04, 2015). doi:10.1117/1.JBO.20.2.025003
History: Received September 22, 2014; Accepted January 7, 2015
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Abstract.  Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and classification of tumors.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Valery P. Zakharov ; Ivan A. Bratchenko ; Dmitry N. Artemyev ; Oleg O. Myakinin ; Dmitry V. Kornilin, et al.
"Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers", J. Biomed. Opt. 20(2), 025003 (Feb 04, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.2.025003


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