JBO Letters

Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques

[+] Author Affiliations
Magnus B. Lilledahl, Pål Gunnar Ellingsen, Vegard Stenhjem Hagen, Morten Kildemo

Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway

Håkan Gustafsson

Linköping University, Department of Clinical Engineering, Radiation Physics, SE-581 83 Linköping, Sweden

Helene Zachrisson

Linköping University, Department of Medical and Health Sciences, SE-581 83 Linköping, Sweden

Martin Hallbeck

Linköping University, Department of Clinical and Experimental Medicine, SE-581 83 Linköping, Sweden

Mikael Lindgren

Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway

Linköping University, Department of Physics, Chemistry and Biology, SE-581 83 Linköping, Sweden

J. Biomed. Opt. 20(2), 020503 (Feb 25, 2015). doi:10.1117/1.JBO.20.2.020503
History: Received December 1, 2014; Accepted January 28, 2015
Text Size: A A A

Abstract.  Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Magnus B. Lilledahl ; Håkan Gustafsson ; Pål Gunnar Ellingsen ; Helene Zachrisson ; Martin Hallbeck, et al.
"Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques", J. Biomed. Opt. 20(2), 020503 (Feb 25, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.2.020503


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.