Research Papers: Imaging

Second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygenation

[+] Author Affiliations
Jiwei Huang

The Ohio State University, Department of Biomedical Engineering, Columbus, Ohio 43210, United States

Shiwu Zhang

University of Science and Technology of China, Department of Precision Machinery and Precision Instrumentation, Hefei, Anhui 230027, China

Surya Gnyawali, Chandan K. Sen

The Ohio State University, Department of Surgery, Columbus, Ohio 43210, United States

Ronald X. Xu

The Ohio State University, Department of Biomedical Engineering, Columbus, Ohio 43210, United States

University of Science and Technology of China, Department of Precision Machinery and Precision Instrumentation, Hefei, Anhui 230027, China

J. Biomed. Opt. 20(3), 036001 (Mar 02, 2015). doi:10.1117/1.JBO.20.3.036001
History: Received September 5, 2014; Accepted January 20, 2015
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Abstract.  We report a second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygen saturation (StO2). The algorithm is based on a forward model of light transport in multilayered skin tissue and an inverse algorithm for StO2 reconstruction. Based on the forward simulation results, a parameter of a second derivative ratio (SDR) is derived as a function of cutaneous tissue StO2. The SDR function is optimized at a wavelength set of 544, 552, 568, 576, 592, and 600 nm so that cutaneous tissue StO2 can be derived with minimal artifacts by blood concentration, tissue scattering, and melanin concentration. The proposed multispectral StO2 imaging algorithm is verified in both benchtop and in vivo experiments. The experimental results show that the proposed multispectral imaging algorithm is able to map cutaneous tissue StO2 in high temporal resolution with reduced measurement artifacts induced by different skin conditions in comparison with other three commercial tissue oxygen measurement systems. These results indicate that the multispectral StO2 imaging technique has the potential for noninvasive and quantitative assessment of skin tissue oxygenation with a high temporal resolution.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Jiwei Huang ; Shiwu Zhang ; Surya Gnyawali ; Chandan K. Sen and Ronald X. Xu
"Second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygenation", J. Biomed. Opt. 20(3), 036001 (Mar 02, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.3.036001


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