Research Papers: Imaging

Structure tensor analysis of serial optical coherence scanner images for mapping fiber orientations and tractography in the brain

[+] Author Affiliations
Hui Wang, Taner Akkin

University of Minnesota, Department of Biomedical Engineering, Minneapolis, Minnesota 55455, United States

Christophe Lenglet

University of Minnesota, Center for Magnetic Resonance Research, Department of Radiology, Minneapolis, Minnesota 55455, United States

J. Biomed. Opt. 20(3), 036003 (Mar 04, 2015). doi:10.1117/1.JBO.20.3.036003
History: Received November 2, 2014; Accepted February 19, 2015
Text Size: A A A

Abstract.  Quantitative investigations of fiber orientation and structural connectivity at microscopic resolution have led to great challenges for current neuroimaging techniques. Here, we present a structure tensor (ST) analysis of ex vivo rat brain images acquired by a multicontrast (MC) serial optical coherence scanner. The ST considers the gradients of images in local neighbors to generate a matrix whose eigen-decomposition can estimate the local features such as the edges, anisotropy, and orientation of tissue constituents. This computational analysis is applied on the conventional- and polarization-based contrasts of optical coherence tomography. The three-dimensional (3-D) fiber orientation maps are computed from the image stacks of sequential scans both at mesoresolution for a global view and at high-resolution for the details. The computational orientation maps demonstrate a good agreement with the optic axis orientation contrast which measures the in-plane fiber orientation. Moreover, tractography is implemented using the directional information extracted from the 3-D ST. The study provides a unique opportunity to leverage MC high-resolution information to map structural connectivity of the whole brain.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Hui Wang ; Christophe Lenglet and Taner Akkin
"Structure tensor analysis of serial optical coherence scanner images for mapping fiber orientations and tractography in the brain", J. Biomed. Opt. 20(3), 036003 (Mar 04, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.3.036003


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.