Research Papers: Sensing

Drop coating deposition Raman spectroscopy of blood plasma for the detection of colorectal cancer

[+] Author Affiliations
Pengpeng Li, Changshui Chen, Xiaoyuan Deng

South China Normal University, Photon and Nano Research Centre for Biosciences, MOE Key Laboratory of Laser Life Science, Guangzhou, Guangdong 510631, China

Hua Mao, Shaoqin Jin

Southern Medical University, Zhujiang Hospital, Department of Gastroenterology, Guangzhou, Guangdong 510282, China

J. Biomed. Opt. 20(3), 037004 (Mar 10, 2015). doi:10.1117/1.JBO.20.3.037004
History: Received October 9, 2014; Accepted January 21, 2015
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Abstract.  We have recently applied the technique of drop coating deposition Raman (DCDR) spectroscopy for colorectal cancer (CRC) detection using blood plasma. The aim of this study was to develop a more convenient and stable method based on blood plasma for noninvasive CRC detection. Significant differences are observed in DCDR spectra between healthy (n=105) and cancer (n=75) plasma from 15 CRC patients and 21 volunteers, particularly in the spectra that are related to proteins, nucleic acids, and β-carotene. The multivariate analysis principal components analysis and the linear discriminate analysis, together with leave-one-out, cross validation were used on DCDR spectra and yielded a sensitivity of 100% (75/75) and specificity of 98.1% (103/105) for detection of CRC. This study demonstrates that DCDR spectroscopy of blood plasma associated with multivariate statistical algorithms has the potential for the noninvasive detection of CRC.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Pengpeng Li ; Changshui Chen ; Xiaoyuan Deng ; Hua Mao and Shaoqin Jin
"Drop coating deposition Raman spectroscopy of blood plasma for the detection of colorectal cancer", J. Biomed. Opt. 20(3), 037004 (Mar 10, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.3.037004


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