Research Papers: Sensing

Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations

[+] Author Affiliations
Irina Mizeva, Peter Frick, Sergey Podtaev

Institute of Continuous Media Mechanics, ak Koroleva 1, Perm 614013, Russia

Costanzo Di Maria, John Allen

Freeman Hospital, Regional Medical Physics Department, Microvascular Diagnostics Service, Newcastle upon Tyne, NE7 7DN, United Kingdom

Newcastle University, Medical School, Institute of Cellular Medicine, Newcastle upon Tyne, NE2 4HH, United Kingdom

J. Biomed. Opt. 20(3), 037007 (Mar 12, 2015). doi:10.1117/1.JBO.20.3.037007
History: Received October 24, 2014; Accepted February 11, 2015
Text Size: A A A

Abstract.  Photoplethysmography (PPG) and laser Doppler flowmetry (LDF) are two recognized optical techniques that can track low-frequency perfusion changes in microcirculation. The aim of this study was to determine, in healthy subjects, the correlation between the techniques for specific low-frequency bands previously defined for microcirculation. Twelve healthy male subjects (age range 18 to 50 years) were studied, with PPG and LDF signals recorded for 20 min from their right and left index (PPG) and middle (LDF) fingers. Wavelet analysis comprised dividing the low-frequency integral wavelet spectrum (IWS) into five established physiological bands relating to cardiac, respiratory, myogenic, neurogenic, and endothelial activities. The correlation between PPG and LDF was quantified using wavelet correlation analysis and Spearman correlation analysis of the median IWS amplitude. The median wavelet correlation between signals (right-left side average) was 0.45 (cardiac), 0.49 (respiratory), 0.86 (myogenic), 0.91 (neurogenic), and 0.91 (endothelial). The correlation of IWS amplitude values (right-left side average) was statistically significant for the cardiac (ρ=0.64, p<0.05) and endothelial (ρ=0.62, p<0.05) bands. This pilot study has shown good correlation between PPG and LDF for specific physiological frequency bands. In particular, the results suggest that PPG has the potential to be a low-cost replacement for LDF for endothelial activity assessments.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Irina Mizeva ; Costanzo Di Maria ; Peter Frick ; Sergey Podtaev and John Allen
"Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations", J. Biomed. Opt. 20(3), 037007 (Mar 12, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.3.037007


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.