Research Papers: Imaging

Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra

[+] Author Affiliations
Lianpeng Zhou, Huajiang Wei, Zhouyi Guo, Ying Liu

South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China

Guoyong Wu

Sun Yat-Sen University, the First Affiliated Hospital, Department of Surgery, 58 Zhongshan 2 Road, Guangzhou, Guangdong Province 510080, China

Hongqin Yang, Shusen Xie

Fujian Normal University, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, 1 Keji Road, Fuzhou, Fujian 350007, China

Yonghong He

Tsinghua University, Graduate School at Shenzhen, 2279 Lishui Road, Shenzhen, Guangdong 518055, China

Qingan Meng

Southwest Institute of Technical Physics, 7 People’s South Road, Chengdu, Sichuan 610041, China

J. Biomed. Opt. 20(4), 046003 (Apr 09, 2015). doi:10.1117/1.JBO.20.4.046003
History: Received December 23, 2014; Accepted March 16, 2015
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Abstract.  The objective is to investigate the effects of two different sized (60 and 100 nm) titanium dioxide (TiO2) nanoparticles (NPs) penetration and accumulation in in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) tissue, and 650-nm diode laser-pretreated tissue on their optical properties studied with optical coherence tomography monitoring and diffuse reflectance (DR) spectra measurement. As with TiO2 NPs penetrating into the tissues, the intensities of DR of the samples increase, and then the enhancements of DR and the attenuation coefficients of the tissues were quantitatively calculated. The results suggest that 650-nm diode laser pretreatment increased the amounts of TiO2 NPs penetration and accumulation in NL and LSCC tissues, and the tissue optical properties were significantly influenced by accumulation of TiO2 NPs.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Lianpeng Zhou ; Guoyong Wu ; Huajiang Wei ; Zhouyi Guo ; Hongqin Yang, et al.
"Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra", J. Biomed. Opt. 20(4), 046003 (Apr 09, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.4.046003


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