JBO Letters

Blood typing using microstructured waveguide smart cuvette

[+] Author Affiliations
Anastasiya A. Zanishevskaya, Yulia S. Skibina

SPE Nanostructured Glass Technology, 101, 50 Let Oktyabrya Avenue, Saratov 410033, Russia

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, Russia

Andrey A. Shuvalov

SPE Nanostructured Glass Technology, 101, 50 Let Oktyabrya Avenue, Saratov 410033, Russia

Saratov State University, Department of Semiconductor Physics, 83 Astrakhanskaya Street, Saratov 410012, Russia

Valery V. Tuchin

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, Russia

Institute of Precise Mechanics and Control RAS, Laboratory of Laser Diagnostics of Technical and Living Systems, 24 Rabochaya Street, Saratov 410028, Russia

Tomsk State University, Laboratory of Biophotonics, 36 Lenin’s Avenue, Tomsk 634050, Russia

J. Biomed. Opt. 20(4), 040503 (Apr 13, 2015). doi:10.1117/1.JBO.20.4.040503
History: Received January 20, 2015; Accepted March 24, 2015
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Abstract.  We introduce a sensitive method that allows one to distinguish positive and negative agglutination reactions used for blood typing and determination of Rh affinity with a high precision. The method is based on the unique properties of photonic crystal waveguides, i.e., microstructured waveguides (MSWs). The transmission spectrum of an MSW smart cuvette filled by a specific or nonspecific agglutinating serum depends on the scattering, refractive, and absorptive properties of the blood probe. This concept was proven in the course of a laboratory clinical study. The obtained ratio of the spectral-based discrimination parameter for positive and negative reactions (I+/I) was found to be 16 for standard analysis and around 2 for used sera with a weak activity.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Topics

Blood ; Waveguides

Citation

Anastasiya A. Zanishevskaya ; Andrey A. Shuvalov ; Yulia S. Skibina and Valery V. Tuchin
"Blood typing using microstructured waveguide smart cuvette", J. Biomed. Opt. 20(4), 040503 (Apr 13, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.4.040503


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