Research Papers: General

Measuring skin aging using optical coherence tomography in vivo: a validation study

[+] Author Affiliations
Carina Trojahn, Gabor Dobos, Claudia Richter, Ulrike Blume-Peytavi, Jan Kottner

Charité-Universitätsmedizin Berlin, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charitéplatz 1, Berlin 10117, Germany

J. Biomed. Opt. 20(4), 045003 (Apr 15, 2015). doi:10.1117/1.JBO.20.4.045003
History: Received February 20, 2015; Accepted March 26, 2015
Text Size: A A A

Abstract.  Dermal and epidermal structures in human skin change during intrinsic and extrinsic aging. Epidermal thickness is one of the most often reported parameters for the assessment of skin aging in cross-sectional images captured by optical coherence tomography (OCT). We aimed to identify further parameters for the noninvasive measurement of skin aging of sun-exposed and sun-protected areas utilizing OCT. Based on a literature review, seven parameters were inductively developed. Three independent raters assessed these parameters using four-point scales on images of female subjects of two age groups. All items could be detected and quantified in our sample. Interrater agreement ranged between 25.0% and 83.3%. The item scores “stratum corneum reflectivity,” “upper dermal reflectivity,” and “dermoepidermal contrast” showed significant differences between age groups on the volar and dorsal forearm indicating that they were best able to measure changes during skin aging. “Surface unevenness” was associated with the skin roughness parameters, Rz and Rmax, on the inner upper arm and volar forearm supporting the criterion validity of this parameter on sun-protected skin areas. Based on the interrater agreement and the ability to differentiate between age groups, these four parameters are being considered as the best candidates for measuring skin aging in OCT images.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Topics

Skin

Citation

Carina Trojahn ; Gabor Dobos ; Claudia Richter ; Ulrike Blume-Peytavi and Jan Kottner
"Measuring skin aging using optical coherence tomography in vivo: a validation study", J. Biomed. Opt. 20(4), 045003 (Apr 15, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.4.045003


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.