Research Papers: Imaging

Organosilicon phantom for photoacoustic imaging

[+] Author Affiliations
Cinzia Avigo, Claudia Kusmic, Francesco Faita

Istituto di Fisiologia Clinica, CNR, Via Giuseppe Moruzzi 1, Pisa 56124, Italy

Nicole Di Lascio

Istituto di Fisiologia Clinica, CNR, Via Giuseppe Moruzzi 1, Pisa 56124, Italy

Scuola Superiore Sant’Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy

Paolo Armanetti

Università di Pisa, Dipartimento di Fisica, Largo Bruno Pontecorvo 3, Pisa 56127, Italy

Lucia Cavigli, Fulvio Ratto, Roberto Pini

Istituto di Fisica Applicata “Nello Carrara,” CNR, Via Madonna del Piano 10, Sesto Fiorentino (FI) 50019, Italy

Sandro Meucci

NEST, Istituto Nanoscienze, CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa 56127, Italy

Center of Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, Pisa 56127, Italy

Cecilia Masciullo, Marco Cecchini

NEST, Istituto Nanoscienze, CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa 56127, Italy

Luca Menichetti

Istituto di Fisiologia Clinica, CNR, Via Giuseppe Moruzzi 1, Pisa 56124, Italy

Fondazione CNR/Regione Toscana G. Monasterio, Via Giuseppe Moruzzi 1, Pisa 56124, Italy

J. Biomed. Opt. 20(4), 046008 (Apr 20, 2015). doi:10.1117/1.JBO.20.4.046008
History: Received January 29, 2015; Accepted March 26, 2015
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Abstract.  Photoacoustic imaging is an emerging technique. Although commercially available photoacoustic imaging systems currently exist, the technology is still in its infancy. Therefore, the design of stable phantoms is essential to achieve semiquantitative evaluation of the performance of a photoacoustic system and can help optimize the properties of contrast agents. We designed and developed a polydimethylsiloxane (PDMS) phantom with exceptionally fine geometry; the phantom was tested using photoacoustic experiments loaded with the standard indocyanine green dye and compared to an agar phantom pattern through polyethylene glycol-gold nanorods. The linearity of the photoacoustic signal with the nanoparticle number was assessed. The signal-to-noise ratio and contrast were employed as image quality parameters, and enhancements of up to 50 and up to 300%, respectively, were measured with the PDMS phantom with respect to the agar one. A tissue-mimicking (TM)-PDMS was prepared by adding TiO2 and India ink; photoacoustic tests were performed in order to compare the signal generated by the TM-PDMS and the biological tissue. The PDMS phantom can become a particularly promising tool in the field of photoacoustics for the evaluation of the performance of a PA system and as a model of the structure of vascularized soft tissues.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Cinzia Avigo ; Nicole Di Lascio ; Paolo Armanetti ; Claudia Kusmic ; Lucia Cavigli, et al.
"Organosilicon phantom for photoacoustic imaging", J. Biomed. Opt. 20(4), 046008 (Apr 20, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.4.046008


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