Research Papers: Therapeutic

Optimization of irradiance for photodynamic therapy of port-wine stain

[+] Author Affiliations
Feng-juan Zhang, Xiao-ming Hu, Qin Li

Beijing Institute of Technology, School of Life Science, Beijing 100081, China

Ya Zhou

Beijing Institute of Technology, School of Optoelectronics, Beijing 100081, China

J. Biomed. Opt. 20(4), 048004 (Apr 24, 2015). doi:10.1117/1.JBO.20.4.048004
History: Received December 13, 2014; Accepted April 1, 2015
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Abstract.  Controllable and effective irradiation of lesions is among the key factors that affect the potency of photodynamic therapy (PDT). An optimization method for the irradiance distribution of treatment was proposed which can be used to improve the efficacy of PDT and allow more lesions to receive the desired irradiance level in a single therapy session. With the proposed digital illumination binocular treatment system, the preferred surface normal vectors, irradiation angles, as well as area and weight coefficients of lesions can be achieved and used as characteristic parameters to optimize the irradiation direction. Two port-wine stain phantom experiments were performed. The comparison of the illumination area between preoptimization and postoptimization showed that the proposed method can effectively guide the light source control, improve the distribution of light dose, and increase the effective treatment area.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Feng-juan Zhang ; Xiao-ming Hu ; Ya Zhou and Qin Li
"Optimization of irradiance for photodynamic therapy of port-wine stain", J. Biomed. Opt. 20(4), 048004 (Apr 24, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.4.048004


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