Research Papers: Sensing

Dynamics of statistically confident particle sizes and concentrations in blood plasma obtained by the dynamic light scattering method

[+] Author Affiliations
Leonid L. Chaikov

Lebedev Physical Institute of the Russian Academy of Sciences, G.S. Landsberg Optical Department, Laboratory for Nonlinear Optics and Light Scattering, 53 Leninskij Prospekt, Moscow 119991, Russia

National Research Nuclear University “MEPhI”, 31 Kashirskoe shosse, Moscow 115409, Russia

Marina N. Kirichenko, Svetlana V. Krivokhizha, Alexander R. Zaritskiy

Lebedev Physical Institute of the Russian Academy of Sciences, G.S. Landsberg Optical Department, Laboratory for Nonlinear Optics and Light Scattering, 53 Leninskij Prospekt, Moscow 119991, Russia

J. Biomed. Opt. 20(5), 057003 (May 05, 2015). doi:10.1117/1.JBO.20.5.057003
History: Received December 20, 2014; Accepted April 6, 2015
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Abstract.  The work is devoted to the study of sizes and concentrations of proteins, and their aggregates in blood plasma samples, using static and dynamic light scattering methods. A new approach is proposed based on multiple repetition of measurements of intensity size distribution and on counting the number of registrations of different sizes, which made it possible to obtain statistically confident particle sizes and concentrations in the blood plasma. It was revealed that statistically confident particle sizes in the blood plasma were stable during 30 h of observations, whereas the concentrations of particles of different sizes varied as a result of redistribution of material between them owing to the protein degradation processes.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Leonid L. Chaikov ; Marina N. Kirichenko ; Svetlana V. Krivokhizha and Alexander R. Zaritskiy
"Dynamics of statistically confident particle sizes and concentrations in blood plasma obtained by the dynamic light scattering method", J. Biomed. Opt. 20(5), 057003 (May 05, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.5.057003


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