JBO Letters

Laser beam coupling into nerve fiber myelin allows one to assess its structural membrane properties

[+] Author Affiliations
Nikolay P. Kutuzov, Alexey R. Brazhe, Georgy V. Maksimov

Moscow State University, Biophysics Department, Biological Faculty, Leninskie Gory 1/12, Moscow 119234, Russia

Vladimir L. Lyaskovskiy

All-Russian Research Institute for Optical and Physical Measurements, Ozernaya 46, Moscow 119361, Russia

J. Biomed. Opt. 20(5), 050501 (May 08, 2015). doi:10.1117/1.JBO.20.5.050501
History: Received March 10, 2015; Accepted April 10, 2015
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Abstract.  We show that myelin, the insulation wrap of nerve fibers, can couple laser light, thus behaving as a single-cell optical device. The effect was employed to map distinct myelin regions based on the coupling efficiency. Raman spectra acquisition allowed us to simultaneously understand the underlying microscopic differences in the membrane lipid ordering degree. The described method potentially provides new capabilities in myelin-associated disease studies and can be used as a handy tool for myelin structure investigation in combination with other methods.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Topics

Lasers ; Nerve

Citation

Nikolay P. Kutuzov ; Alexey R. Brazhe ; Vladimir L. Lyaskovskiy and Georgy V. Maksimov
"Laser beam coupling into nerve fiber myelin allows one to assess its structural membrane properties", J. Biomed. Opt. 20(5), 050501 (May 08, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.5.050501


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