Research Papers: Imaging

Optimal flushing agents for integrated optical and acoustic imaging systems

[+] Author Affiliations
Jiawen Li, Zhongping Chen

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92617, United States

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697-2700, United States

Hataka Minami, Claire Robertson

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697-2700, United States

Earl Steward, Dilbahar Mohar, Pranav Patel

University of California, Irvine, Medical Center, 101 The City Drive South, Orange, California 92868, United States

Teng Ma, Kirk Shung, Qifa Zhou

NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California 90089, United States

J. Biomed. Opt. 20(5), 056005 (May 18, 2015). doi:10.1117/1.JBO.20.5.056005
History: Received February 19, 2015; Accepted April 20, 2015
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Abstract.  An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and in vivo on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Jiawen Li ; Hataka Minami ; Earl Steward ; Teng Ma ; Dilbahar Mohar, et al.
"Optimal flushing agents for integrated optical and acoustic imaging systems", J. Biomed. Opt. 20(5), 056005 (May 18, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.5.056005


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