Research Papers: Sensing

Ammonia and ethylene biomarkers in the respiration of the people with schizophrenia using photoacoustic spectroscopy

[+] Author Affiliations
Cristina Popa

National Institute for Laser, Plasma and Radiation Physic, Laser Department, 409 Atomistilor Street, PO Box MG-36, 077125 Magurele, Romania

University Politehnica of Bucharest, Faculty of Applied Sciences, Physics Department, 313 Splaiul Independentei, Bucharest 060042, Romania

Mioara Petrus, Ana Maria Bratu

National Institute for Laser, Plasma and Radiation Physic, Laser Department, 409 Atomistilor Street, PO Box MG-36, 077125 Magurele, Romania

J. Biomed. Opt. 20(5), 057006 (May 28, 2015). doi:10.1117/1.JBO.20.5.057006
History: Received December 4, 2014; Accepted May 5, 2015
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Abstract.  Oxidative stress has become an exciting area of schizophrenia (SCZ) research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to new treatment strategies. The first objective of the present study was to analyze the oxidative stress markers in breath samples of patients with SCZ before and after the treatment with Levomepromazine. The second objective was to analyze the deficiency of amino acids marker in breath samples of patients with SCZ before and after the treatment. Exhaled breath was collected from 15 SCZ patients and 19 healthy controls; subsequently, CO2 laser photoacoustic spectroscopy was used to assess the exhaled breath compounds of the study subjects. One of the main breath biomarkers of the oxidative stress is ethylene, while one of the main breath biomarkers of the amino acids deficiency is ammonia. The breath biomarkers in the exhalation of SCZ patients exhibited significant differences from the breath biomarkers in the exhalation of healthy controls. Analysis of breath ethylene and breath ammonia provides a related model of SCZ exhalation that could represent an effective and convenient screening method for this intellectual disability.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Cristina Popa ; Mioara Petrus and Ana Maria Bratu
"Ammonia and ethylene biomarkers in the respiration of the people with schizophrenia using photoacoustic spectroscopy", J. Biomed. Opt. 20(5), 057006 (May 28, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.5.057006


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