Research Papers: General

High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter

[+] Author Affiliations
Yan Li, Xiaojing Gong, Riqiang Lin, Xiaosong Bai

Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key Laboratory of Health Informatics of Chinese Academy of Sciences, 1068 Xueyuan Boulevard, Shenzhen 518055, China

Chengbo Liu, Liang Song

Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key Laboratory of Health Informatics of Chinese Academy of Sciences, 1068 Xueyuan Boulevard, Shenzhen 518055, China

Beijing Center for Mathematics and Information Interdisciplinary Sciences (BCMIIS), Beijing 100190, China

William Hau

University of Hong Kong, Institute of Cardiovascular Medicine and Research, Li Ka Shing Faculty of Medicine, Hong Kong, China

J. Biomed. Opt. 20(6), 065006 (Jun 22, 2015). doi:10.1117/1.JBO.20.6.065006
History: Received February 25, 2015; Accepted May 28, 2015
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Abstract.  Intravascular spectroscopic photoacoustic technology can image atherosclerotic plaque composition with high sensitivity and specificity, which is critical for identifying vulnerable plaques. Here, we designed and engineered a catheter of 0.9 mm in diameter for intravascular photoacoustic (IVPA) imaging, smaller than the critical size of 1 mm required for clinical translation. Further, a quasifocusing photoacoustic excitation scheme was developed for the catheter, producing well-detectable IVPA signals from stents and lipids with a laser energy as low as 30μJ/pulse. As a result, this design enabled the use of a low-energy, high-repetition rate, ns-pulsed optical parametric oscillator laser for high-speed spectroscopic IVPA imaging at both the 1.2-μm and 1.7-μm spectral bands for lipid detection. Specifically, for each wavelength, a 1-kHz IVPA A-line rate was achieved, 100-fold faster than previously reported IVPA systems offering a similar wavelength tuning range. Using the system, spectroscopic IVPA imaging of peri-adventitial adipose tissue from a porcine aorta segment was demonstrated. The significantly improved imaging speed, together with the reduced catheter size and multiwavelength spectroscopic imaging ability, suggests that the developed high-speed IVPA technology is of great potential to be further translated for in vivo applications.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Yan Li ; Xiaojing Gong ; Chengbo Liu ; Riqiang Lin ; William Hau, et al.
"High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter", J. Biomed. Opt. 20(6), 065006 (Jun 22, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.6.065006


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